Dr. Sreeja S.
Current Position: Post- doctoral fellow
University College Cork, Ireland
Project Completed: Development of therapeutically active bone scaffolds (DST- SERB)
National Post-doctoral Fellow
Email Id: ssreeja@cusat.ac.in; sreebio14@gmail.com
linkedin.com/in/sreeja-s-867b345a
Dr. Sreeja is a SERB National Post-doctoral fellow (NPDF) in Prof. G.S. Sailaja’s team at the Department of Polymer Science and Rubber Technology since February 2021. She received her Bachelor’s and Master’s degree in Biochemistry with good academic records. She obtained her Ph.D. degree in Biochemistry from Mahatma Gandhi University, Kerala, in 2017 under the supervision of Dr. C.K.K. Nair, where her research focused on solid-tumor hypoxia targeting therapeutic system. Then she joined Prof. Sailaja’s group in 2018 as Post-doctoral fellow and focused on the development of polymer-based biomaterials for bone tissue regeneration and a few academic activities in the department. She has been awarded the prestigious SERB-NPDF position in the same group in 2021. She presently aims on understanding the mechanism of osteogenesis in surface-functionalized biodegradable polymers. She is a life member of the Society of Biomaterials and Artificial Organs (SBAO), India.
Research interests
Cell-material interactions; Bone regeneration; Biocompatible materials
Awards
o SERB-National Post-doctoral fellowship, 2021
o University Post-doctoral fellowship, 2018
o Best poster award - International conference on Radiation Research, 2016
o eLife poster award – International Conference on NextGen Genomics, Biology, Bioinformatics and Technologies, 2015
o UGC-Junior Research Fellowship, 2010
o GATE, 2011
Publications (2015 onwards)
o K.R. Sneha, S. Sreeja, G.S. Sailaja, Radiopacity endowed magnetic nanocomposite with hyperthermia and in vitro mineralization potential: a combinatorial therapeutic system for osteosarcoma. Biomed Mater. 2021 May 28;16(4). doi: 10.1088/1748-605X/ac01af. PMID: 34061045.
o S. Sreeja S., Parameshwar R., Varma P.R.H., G.S. Sailaja. Hierarchically Porous Osteoinductive Poly(hydroxyethyl methacrylate-co-methyl methacrylate) Scaffold with Sustained Doxorubicin Delivery for Consolidated Osteosarcoma Treatment and Bone Defect Repair. ACS Biomater Sci Eng. 2021 Feb 8;7(2):701-717. doi: 10.1021/acsbiomaterials.0c01628.
o S. Sreeja, C.V. Muraleedharan, P.R. Harikrishna Varma and G.S. Sailaja. Surface-transformed osteoinductive polyethylene terephthalate scaffold as a dual system for bone tissue regeneration with localized antibiotic delivery. Mater. Sci. Eng. C. 2019; 109, 110491. (IF: 5.880).
o S. Sreeja, A. Manoharan and K. Venkataraman. Oxidised lipoproteins as a diagnostic target for Cardiovascular Diseases. Curr. Sci. 2018; 115(7):1276-1286. DOI: 10.18520/cs/v115/i7/1276-1286.
o S. Sreeja, Nair CKK. Tumor control by hypoxia-specific chemotargeting of iron-oxide nanoparticle - Berberine complexes in a mouse model. Life Sci. 2018; 195:71-80. doi:10.1016/j.lfs.2017.12.036.
o S. Sreeja, Nair CKK. Chemo-directed specific targeting of nanoparticle - doxorubicin complexes to tumor in animal model. J Drug Deliv Sci Technol. 2016; 31:167-175. DOI: http://dx.doi.org/10.1016/j.jddst.2016.01.003.
o S. Sreeja, Nair CKK. Anticancer Property of Iron-Oxide Nanoparticle - Drug Complexes: An In vitro Study. J Environ Pathol Toxicol Oncol. 2015; 34(3):183-9. DOI:10.1615/JEnviron PatholToxicolOncol.2015013482.
Patent
G.S. Sailaja, Praseetha R. Nair, S. Sreeja Porous biodegradable scaffold for regenerative bone tissue engineering. Indian patent application no. 202141026897 dated June 16, 2021.
Conference Presentations (2015 onwards)
o Sreeja S., Sailaja G.S. Methionine Doped Chitosan-Based Carbon Quantum Dots for Biomedical Applications. 11th World Biomaterials Congress - virtual (2020) - Poster presentation
o Sreeja S., Nandhini M., Sailaja G.S. Surface Engineered Fluorescent Graphene Quantum Dots for Cellular Imaging. 2nd International Conference on Nanoscience and Nanotechology (ICNAN 2019) (2019) – Oral Presentation
o Sreeja S., Muraleedharan C.V., Harikrishna Varma P.R. and Sailaja G.S. Bifunctional Antibiotic Delivery System with Intrinsic Bone Regeneration Potential. International Conference on Biomaterial-Based Therapeutic Engineering and Regenerative Medicine (BioTerm) (2019) - Poster presentation
o Sreeja S., Muraleedharan C.V., Harikrishna Varma P.R. and Sailaja G.S. Antimicrobial Drug-Loaded Osteoinductive Polymeric Scaffold for the treatment of Osteomyelitis. International Conference on ‘Materials for the Millenium - MATCON 2019’ - Poster presentation
o Sreeja S., Krishnan Venkataraman and Anand Manoharan. Myeloperoxidase (MPO) and Malondialdehyde (MDA) as Risk Predictors of Cardiovascular Diseases (CVD) – A Case Control Study. Recent Biochemical Approaches in Therapeutics organized by Department of Biochemistry (National level) (2017) – Oral presentation
o S. Sreeja, Nair C.K.K. Evaluation of Hypoxia-Specific Targeting of Iron Oxide Nanoparticle - Doxorubicin - Sanazole Complexes against Solid Tumour. 36th annual conference of Indian Association for Cancer Research (2017) – Poster presentation
o S. Sreeja, Nair C.K.K. Directing nanoparticle- drug complexes to solid tumor by hypoxic cell radiosensitizer. International conference on Radiation Research (2016) – Poster presentation (Best Poster Award)
o S. Sreeja, Nair C.K.K. Chemo-Directed Targeting of Nanoparticle-drug Complexes to Tumor: Preclinical Evaluation of Therapeutic Efficacy and Gene Expression. 28th Kerala Science congress, Malappuram (2016) – Oral presentation
o S. Sreeja, Nair C.K.K. Hypoxia specific targeting of nanoparticle-drug complex: tumor regression and expression of hif-1α and its target genes. International conference on NextGen Genomics, Biology, Bioinformatics and Technologies (2015) - Poster Presentation (Best Poster Award)