Regenerative Biomaterials and Theranostics Laboratory

Papers

We publish national/international patents and high-impact peer-reviewed research papers in leading journals across diverse topics including biomaterials and polymers for bone regeneration, antibacterial formulations, nanomedicine, and theranostic materials. You can find a selection of our papers below.

Highlighted

Bismuth Fe3O4 in situ metal organic framework nanocomposite for image guided magnetic hyperthermia therapy
Bismuth/Fe3O4 in situ metal organic framework nanocomposite for image guided magnetic hyperthermia therapy
Liz Hannah George, S. Prathapan, Nishad K․ V․, Manoj Komath, G.S. Sailaja
Materials Research Bulletin  ·  01 Jun 2025  ·  doi:10.1016/j.materresbull.2025.113339
We present a bismuth/Fe3O4 metal-organic framework (BiTP/Fe3O4) nanocomposite designed for synergistic, image-guided cancer therapy. This system integrates CT imaging-leveraging the high radiopacity of bismuth (2981.8 HU) with magnetic hyperthermia via surface-anchored Fe3O4 nanoparticles (reaching 42.1°C within 7 min). The nanocomposite demonstrates excellent cytocompatibility, with Prussian blue staining confirming preferential uptake in human osteosarcoma cells, validating its potential for targeted magnetic hyperthermia applications.

Journal Articles

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2026

Harnessing the potential of antibiotic functionalized coir nanocellulose in sustainable wound management
Harnessing the potential of antibiotic functionalized coir nanocellulose in sustainable wound management
M. G. Geena, Ajith Sudhakaran, K. P. Akhila, Anita Das Ravindranath, Rahul Rajan, Athira Johnson, G. S. Sailaja
Polymers from Renewable Resources  ·  17 Jul 2026  ·  doi:10.1177/20412479261468650

2025

Bismuth Fe3O4 in situ metal organic framework nanocomposite for image guided magnetic hyperthermia therapy
Bismuth/Fe3O4 in situ metal organic framework nanocomposite for image guided magnetic hyperthermia therapy
Liz Hannah George, S. Prathapan, Nishad K․ V․, Manoj Komath, G.S. Sailaja
Materials Research Bulletin  ·  01 Jun 2025  ·  doi:10.1016/j.materresbull.2025.113339
We present a bismuth/Fe3O4 metal-organic framework (BiTP/Fe3O4) nanocomposite designed for synergistic, image-guided cancer therapy. This system integrates CT imaging-leveraging the high radiopacity of bismuth (2981.8 HU) with magnetic hyperthermia via surface-anchored Fe3O4 nanoparticles (reaching 42.1°C within 7 min). The nanocomposite demonstrates excellent cytocompatibility, with Prussian blue staining confirming preferential uptake in human osteosarcoma cells, validating its potential for targeted magnetic hyperthermia applications.
Cissus quadrangularis L. hexane extract infused glyoxal cross-linked chitosan-collagen scaffold elicits early osteoinduction
Cissus quadrangularis L. hexane extract infused glyoxal cross-linked chitosan-collagen scaffold elicits early osteoinduction
Praseetha R. Nair, P.S. Unnikrishnan, Sachin J. Shenoy, G.S. Sailaja
Phytomedicine Plus  ·  01 Feb 2025  ·  doi:10.1016/j.phyplu.2024.100668

2024

Lawsonia inermis-organically modified chitosan intercalated bentonite clay: A multifunctional nanotheranostic system for controlled drug delivery, sensing and cellular imaging
Lawsonia inermis-organically modified chitosan intercalated bentonite clay: A multifunctional nanotheranostic system for controlled drug delivery, sensing and cellular imaging
P. Sirajunnisa, S. Sreelakshmi, G.S. Sailaja
International Journal of Biological Macromolecules  ·  01 Mar 2024  ·  doi:10.1016/j.ijbiomac.2024.130209
Cissus Quadrangularis L. Hexane Extract Infused Glyoxal Cross-Linked Chitosan-Collagen Scaffold Elicits Early Osteoinduction
Cissus Quadrangularis L. Hexane Extract Infused Glyoxal Cross-Linked Chitosan-Collagen Scaffold Elicits Early Osteoinduction
Praseetha R. Nair, Unnikrishnan P. S., Sachin J. Shenoy, Sailaja G S
Elsevier BV  ·  01 Jan 2024  ·  doi:10.2139/ssrn.4909101

2023

Chitosan-TEMPO-Oxidized Nanocellulose Magnetic Responsive Patches with Hyperthermia Potential for Smart Melanoma Therapy
Chitosan-TEMPO-Oxidized Nanocellulose Magnetic Responsive Patches with Hyperthermia Potential for Smart Melanoma Therapy
N. S. Sumitha, Nidhi G. Krishna, G. S. Sailaja
ACS Applied Polymer Materials  ·  19 Oct 2023  ·  doi:10.1021/acsapm.3c01654
Room temperature synthesized metal organic frameworks of Lawsonia inermis: Potential candidates for sensing and cellular imaging
Room temperature synthesized metal organic frameworks of Lawsonia inermis: Potential candidates for sensing and cellular imaging
P. Sirajunnisa, S. Sreelakshmi, S. Prathapan, G.S. Sailaja
Journal of Luminescence  ·  01 Sep 2023  ·  doi:10.1016/j.jlumin.2023.119899
Aqueous Cissus quadrangularis Stem Extract Integrated Biodegradable Tissue Engineering Scaffold Augments Early Biomimetic and Biomineralization In Vitroe
Aqueous Cissus quadrangularis Stem Extract Integrated Biodegradable Tissue Engineering Scaffold Augments Early Biomimetic and Biomineralization In Vitroe
Praseetha R. Nair, S. Sreeja, G. S. Sailaja
The Society for Biomaterials and Artificial Organs (India)  ·  30 Jun 2023  ·  [no id info]
Natural rubber latex films with effective growth inhibition against i S. aureus i via surface conjugated gentamicin
Natural rubber latex films with effective growth inhibition against S. aureus via surface conjugated gentamicin
Aswin Arakkal, Paramban Sirajunnisa, Gopalakrishnanchettiar Sivakamiammal Sailaja
Journal of Bioactive and Compatible Polymers  ·  06 Mar 2023  ·  doi:10.1177/08839115231153823
A long-lived photoluminescent silver nanocluster-infused silver terephthalate metal organic framework with antibacterial and biofilm inhibition activity: a high functional resource
A long-lived photoluminescent silver nanocluster-infused silver terephthalate metal organic framework with antibacterial and biofilm inhibition activity: a high functional resource
Liz Hannah George, Sreedharan Prathapan, Narayanapillai Manoj, Prasanth Rathinam, Salbi Aadithya, G. S. Sailaja
Journal of Materials Chemistry C  ·  01 Jan 2023  ·  doi:10.1039/D3TC01033C

2022

Multifunctional chitosan ferrogels for targeted cancer therapy by on-demand magnetically triggered drug delivery and hyperthermia
Multifunctional chitosan ferrogels for targeted cancer therapy by on-demand magnetically triggered drug delivery and hyperthermia
N.S. Sumitha, Nidhi G. Krishna, G.S. Sailaja
Biomaterials Advances  ·  01 Nov 2022  ·  doi:10.1016/j.bioadv.2022.213137
Antibacterial natural rubber latex films with surface-anchored quaternary poly 4-vinylpyridine polyelectrolyte
Antibacterial natural rubber latex films with surface-anchored quaternary poly(4-vinylpyridine) polyelectrolyte
Aswin Arakkal, Prasanth Rathinam, P. Sirajunnisa, Honey Gopinathan, Ajith Vengellur, Sarita G. Bhat, G.S. Sailaja
Reactive and Functional Polymers  ·  01 Mar 2022  ·  doi:10.1016/j.reactfunctpolym.2022.105190
Lawsone-bentonite hybrid systems for pH-dependent sustained release of ciprofloxacin
Lawsone-bentonite hybrid systems for pH-dependent sustained release of ciprofloxacin
P. Sirajunnisa, Cheemadan Sabna, A. Aswin, S. Prathapan, G. S. Sailaja
New Journal of Chemistry  ·  01 Jan 2022  ·  doi:10.1039/D2NJ00288D

2021

Injectable polyelectrolyte complex-nascent HAP biodegradable antibiotic delivery system for the treatment of osteomyelitis
Injectable polyelectrolyte complex-nascent HAP biodegradable antibiotic delivery system for the treatment of osteomyelitis
Liz Hannah George, Aswin Arakkal, Prathapan Sreedharan, G S Sailaja
Biomedical Materials  ·  08 Dec 2021  ·  doi:10.1088/1748-605X/ac37c5
A dual functional superparamagnetic system with pH-dependent drug release and hyperthermia potential for chemotherapeutic applications
A dual functional superparamagnetic system with pH-dependent drug release and hyperthermia potential for chemotherapeutic applications
N.S. Sumitha, S. Sreeja, P.J. George Varghese, G.S. Sailaja
Materials Chemistry and Physics  ·  01 Nov 2021  ·  doi:10.1016/j.matchemphys.2021.125108
In vitro biomineralization and osteogenesis of Cissus quadrangularis stem extracts: An osteogenic regulator for bone tissue engineering
In vitro biomineralization and osteogenesis of Cissus quadrangularis stem extracts: An osteogenic regulator for bone tissue engineering
Praseetha R. Nair, S. Sreeja, G. S. Sailaja
Journal of Biosciences  ·  08 Sep 2021  ·  doi:10.1007/s12038-021-00206-x
Degradation-Dependent Controlled Delivery of Doxorubicin by Glyoxal Cross-Linked Magnetic and Porous Chitosan Microspheres
Degradation-Dependent Controlled Delivery of Doxorubicin by Glyoxal Cross-Linked Magnetic and Porous Chitosan Microspheres
Nechikkottil Sivadasan Sumitha, Prabha Prakash, Balagopal N. Nair, Gopalakrishnanchettiar Sivakamiammal Sailaja
ACS Omega  ·  09 Aug 2021  ·  doi:10.1021/acsomega.1c02303
Active bayerite underpinned Ag2O Ag: an efficient antibacterial nanohybrid combating microbial contamination
Active bayerite underpinned Ag2O/Ag: an efficient antibacterial nanohybrid combating microbial contamination
Irthasa Aazem, Prasanth Rathinam, Saju Pillai, Gopinathan Honey, Ajith Vengellur, Sarita G Bhat, G S Sailaja
Metallomics  ·  01 Aug 2021  ·  doi:10.1093/mtomcs/mfab049
Lawsone derived Zn scp ii scp and Fe scp iii scp metal organic frameworks with pH dependent emission for controlled drug delivery
Lawsone derived Zn(ii) and Fe(iii) metal organic frameworks with pH dependent emission for controlled drug delivery
P. Sirajunnisa, Liz Hannah George, N. Manoj, S. Prathapan, G. S. Sailaja
New Journal of Chemistry  ·  01 Jan 2021  ·  doi:10.1039/D1NJ01913A

2020

Antibacterial Polyelectrolytic chitosan derivatives conjugated natural rubber latex films with minimized bacterial adhesion
Antibacterial Polyelectrolytic chitosan derivatives conjugated natural rubber latex films with minimized bacterial adhesion
Aswin Arakkal, Irthasa Aazem, Gopinathan Honey, Ajith Vengellur, Sarita G. Bhat, Gopalakrishnan Chettiar S. Sailaja
Journal of Applied Polymer Science  ·  14 Jul 2020  ·  doi:10.1002/app.49608
Surface-transformed osteoinductive polyethylene terephthalate scaffold as a dual system for bone tissue regeneration with localized antibiotic delivery
Surface-transformed osteoinductive polyethylene terephthalate scaffold as a dual system for bone tissue regeneration with localized antibiotic delivery
S. Sreeja, C.V. Muraleedharan, P.R. Harikrishna Varma, G.S. Sailaja
Materials Science and Engineering: C  ·  01 Apr 2020  ·  doi:10.1016/j.msec.2019.110491
Fe3 stabilized 3D cross-linked glycine-melamine formaldehyde networks as precursor for highly efficient oxygen reduction catalyst in alkaline media
Fe3+ stabilized 3D cross-linked glycine-melamine formaldehyde networks as precursor for highly efficient oxygen reduction catalyst in alkaline media
Shijina Kottarathil, Rajith Illathvalappil, Nisa S., Sailaja G.S., Peer Mohamed A., Balagopal N. Nair, Anilkumar Gopinathan M., Sreekumar Kurungot, Takeo Yamaguchi, Hareesh U.S.
Materials Letters  ·  01 Apr 2020  ·  doi:10.1016/j.matlet.2020.127365
Amino acid inspired tunable superparamagnetic iron oxide SPION nanostructures with high magnetic hyperthermia potential for biofunctional applications
Amino acid inspired tunable superparamagnetic iron oxide (SPION) nanostructures with high magnetic hyperthermia potential for biofunctional applications
Ananjana K., Swetha S., Prabha Prakash, K. V. Nishad, Manoj Komath, Balagopal N. Nair, Sailaja G. S.
New Journal of Chemistry  ·  01 Jan 2020  ·  doi:10.1039/C9NJ05343C

2019

Electro-oxidation competency of palladium nanocatalysts over ceria carbon composite supports during alkaline ethylene glycol oxidation
Electro-oxidation competency of palladium nanocatalysts over ceria–carbon composite supports during alkaline ethylene glycol oxidation
Sasidharan Sankar, Naoto Watanabe, Gopinathan M. Anilkumar, Balagopal N. Nair, Sailaja G. Sivakamiammal, Takanori Tamaki, Takeo Yamaguchi
Catalysis Science & Technology  ·  01 Jan 2019  ·  doi:10.1039/C8CY02232A

2018

Melamine formaldehyde metal organic gel interpenetrating polymer network derived intrinsic Fe N-doped porous graphitic carbon electrocatalysts for oxygen reduction reaction
Melamine formaldehyde–metal organic gel interpenetrating polymer network derived intrinsic Fe–N-doped porous graphitic carbon electrocatalysts for oxygen reduction reaction
Kottarathil Shijina, Rajith Illathvalappil, N. S. Sumitha, G. S. Sailaja, Sreekumar Kurungot, Balagopal N. Nair, A. Peer Mohamed, Gopinathan M. Anilkumar, Takeo Yamaguchi, U. S. Hareesh
New Journal of Chemistry  ·  01 Jan 2018  ·  doi:10.1039/C8NJ03170C

2017

Chitosan Intercalated Metal Organic Gel as a Green Precursor of Fe Entrenched and Fe Distributed N Doped Mesoporous Graphitic Carbon for Oxygen Reduction Reaction
Chitosan Intercalated Metal Organic Gel as a Green Precursor of Fe Entrenched and Fe Distributed N‐Doped Mesoporous Graphitic Carbon for Oxygen Reduction Reaction
Kottarathil Shijina, Rajith Illathvalappil, Sreekumar Kurungot, Balagopal N. Nair, A. Peer Mohamed, Takeo Yamaguchi, Gopinathan M. Anilkumar, U. S. Hareesh, G. S. Sailaja
ChemistrySelect  ·  29 Sep 2017  ·  doi:10.1002/slct.201701416

2016

Biomimetic approaches with smart interfaces for bone regeneration
Biomimetic approaches with smart interfaces for bone regeneration
G. S. Sailaja, P. Ramesh, Sajith Vellappally, Sukumaran Anil, H. K. Varma
Journal of Biomedical Science  ·  05 Nov 2016  ·  doi:10.1186/s12929-016-0284-x

2015

Aniosotropically Organized LDH on PVDF: A Geometrically Templated Electrospun Substrate for Advanced Anion Conducting Membranes
Aniosotropically Organized LDH on PVDF: A Geometrically Templated Electrospun Substrate for Advanced Anion Conducting Membranes
G. S. Sailaja, Peilin Zhang, Gopinathan M. Anilkumar, Takeo Yamaguchi
ACS Applied Materials & Interfaces  ·  18 Mar 2015  ·  doi:10.1021/acsami.5b00532
A durable anion conducting membrane with packed anion-exchange sites and an aromatic backbone for solid-state alkaline fuel cells
A durable anion conducting membrane with packed anion-exchange sites and an aromatic backbone for solid-state alkaline fuel cells
G. S. Sailaja, Shoji Miyanishi, Takeo Yamaguchi
Polymer Chemistry  ·  01 Jan 2015  ·  doi:10.1039/C5PY01058F

2014

Amino acid inspired microscale organization of metallic nanocrystals
Amino acid inspired microscale organization of metallic nanocrystals
G. S. Sailaja, Balagopal N. Nair, Julian D. Gale, Takeo Yamaguchi
J. Mater. Chem. A  ·  01 Jan 2014  ·  doi:10.1039/C3TA13540C

2012

The secreted protein acidic and rich in cysteine SPARC induces endoplasmic reticulum stress leading to autophagy-mediated apoptosis in neuroblastoma
The secreted protein acidic and rich in cysteine (SPARC) induces endoplasmic reticulum stress leading to autophagy-mediated apoptosis in neuroblastoma
G.S. SAILAJA, PRAVEEN BHOOPATHI, BHARATHI GORANTLA, CHANDRAMU CHETTY, VENKATESWARA RAO GOGINENI, KIRAN KUMAR VELPULA, CHRISTOPHER S. GONDI, JASTI S. RAO
International Journal of Oncology  ·  24 Oct 2012  ·  doi:10.3892/ijo.2012.1678
Notch signaling regulates tumor-induced angiogenesis in SPARC-overexpressed neuroblastoma
Notch signaling regulates tumor-induced angiogenesis in SPARC-overexpressed neuroblastoma
Bharathi Gorantla, Praveen Bhoopathi, Chandramu Chetty, Venkateswara Rao Gogineni, G. S. Sailaja, Christopher S. Gondi, Jasti S. Rao
Angiogenesis  ·  06 Sep 2012  ·  doi:10.1007/s10456-012-9301-1
Abstract 4758: Self-assembled superparamagnetic iron oxide nanoparticles for targeted cancer therapy
Abstract 4758: Self-assembled superparamagnetic iron oxide nanoparticles for targeted cancer therapy
G. S. Sailaja, Christopher S. Gondi, Praveen Bhoopathi, Bharathi Gorantla, Jasti S. Rao
Cancer Research  ·  01 Apr 2012  ·  doi:10.1158/1538-7445.AM2012-4758
Abstract 4992: SPARC overexpression induces ER stress leading to autophagy-mediated apoptosis in neuroblastoma cells
Abstract 4992: SPARC overexpression induces ER stress leading to autophagy-mediated apoptosis in neuroblastoma cells
G. S. Sailaja, Praveen Bhoopathi, Bharathi Gorantla, Andrew J. Tsung, Jasti S. Rao
Cancer Research  ·  01 Apr 2012  ·  doi:10.1158/1538-7445.AM2012-4992

2011

Effect of surface functionalization on the physicomechanical properties of a novel biofunctional copolymer
Effect of surface functionalization on the physicomechanical properties of a novel biofunctional copolymer
Gopalakrishnanchettiar Sivakamiammal Sailaja, Parameswar Ramesh, Harikrishna Varma
Journal of Applied Polymer Science  ·  12 Apr 2011  ·  doi:10.1002/app.34157

2010

Ultrastructural evaluation of in vitro mineralized calcium phosphate phase on surface phosphorylated poly hydroxy ethyl methacrylate-co-methyl methacrylate
Ultrastructural evaluation of in vitro mineralized calcium phosphate phase on surface phosphorylated poly(hydroxy ethyl methacrylate-co-methyl methacrylate)
G. S. Sailaja, P. Ramesh, H. K. Varma
Journal of Materials Science: Materials in Medicine  ·  23 Jan 2010  ·  doi:10.1007/s10856-010-3987-7

2009

Surface-Phosphorylated Copolymer Promotes Direct Bone Bonding
Surface-Phosphorylated Copolymer Promotes Direct Bone Bonding
Sailaja S. Gopalakrishnanchettiyar, Mira Mohanty, Thrikkovil V. Kumary, Mohanan P. Valappil, Ramesh Parameshwaran, Harikrishna K. Varma
Tissue Engineering Part A  ·  01 Oct 2009  ·  doi:10.1089/ten.tea.2008.0454
Bioinspired mineralization and cell adhesion on surface functionalized poly vinyl alcohol films
Bioinspired mineralization and cell adhesion on surface functionalized poly(vinyl alcohol) films
G.S. Sailaja, K. Sreenivasan, Y. Yokogawa, T.V. Kumary, H.K. Varma
Acta Biomaterialia  ·  01 Jun 2009  ·  doi:10.1016/j.actbio.2008.12.005

2007

Hydroxyapatite moldable formulation using natural rubber latex as binder
Hydroxyapatite moldable formulation using natural rubber latex as binder
G. S. Sailaja, P. Ramesh, H. K. Varma
Journal of Biomedical Materials Research Part B: Applied Biomaterials  ·  06 Jun 2007  ·  doi:10.1002/jbm.b.30725

2006

Human osteosarcoma cell adhesion behaviour on hydroxyapatite integrated chitosan poly acrylic acid polyelectrolyte complex
Human osteosarcoma cell adhesion behaviour on hydroxyapatite integrated chitosan–poly(acrylic acid) polyelectrolyte complex
G.S. Sailaja, P. Ramesh, T.V. Kumary, H.K. Varma
Acta Biomaterialia  ·  01 Nov 2006  ·  doi:10.1016/j.actbio.2006.05.011
Biomimetically modified Poly 2-hydroxy ethyl methacrylate-co-methyl methacrylate microspheres for bone augmentation
Biomimetically modified Poly (2-hydroxy ethyl methacrylate-co-methyl methacrylate) microspheres for bone augmentation
Sailaja G. S., Kumary T. V., Varma H. K.
Society for Biomaterials and Artificial Organs  ·  30 Jul 2006  ·  [no id info]
In Vitro Mineralization and Cell Adhesion on Surface Modified Poly 2 - hydroxy ethyl methacrylate-co-methyl methacrylate
In Vitro Mineralization and Cell Adhesion on Surface Modified Poly (2 - hydroxy ethyl methacrylate-co-methyl methacrylate
G.S. Sailaja, T.V. Kumari, Yoshiyuki Yokogawa, H.K. Varma
Key Engineering Materials  ·  01 May 2006  ·  doi:10.4028/www.scientific.net/KEM.309-311.493
Swelling behavior of hydroxyapatite filled chitosan poly acrylic acid polyelectrolyte complexes
Swelling behavior of hydroxyapatite‐filled chitosan–poly(acrylic acid) polyelectrolyte complexes
G. S. Sailaja, P. Ramesh, H. K. Varma
Journal of Applied Polymer Science  ·  29 Mar 2006  ·  doi:10.1002/app.23058

2003

Hydroxyapatite filled chitosan-polyacrylic acid polyelectrolyte complexes
Hydroxyapatite filled chitosan-polyacrylic acid polyelectrolyte complexes
G. S. Sailaja, S. Velayudhan, M. C. Sunny, K. Sreenivasan, H. K. Varma, P. Ramesh
Journal of Materials Science  ·  01 Sep 2003  ·  doi:10.1023/A:1025689701309